{"product_id":"sn-38-s4908","title":"SN-38","description":"\u003cp\u003e\u003cstrong\u003eSN-38\u003c\/strong\u003e is an inhibitor of Topoisomerase used in studies of DNA Damage Response and Autophagy. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control and autophagic flux, lysosomal turnover, and stress adaptation in autophagy, cancer, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Topoisomerase, SN-38 can be used to examine checkpoint activation, DNA repair, and genome-stability control and autophagic flux, lysosomal turnover, and stress adaptation. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Topoisomerase\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Autophagy\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, SN-38 is appropriate when a defined chemical perturbant is needed to connect Topoisomerase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809130258777,"sku":"S4908-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809130291545,"sku":"S4908-50MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809130324313,"sku":"S4908-1G","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809130357081,"sku":"S4908-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/SN-38-chemical-structure-s4908.gif?v=1776197267","url":"https:\/\/absource.de\/products\/sn-38-s4908","provider":"Absource Diagnostics","version":"1.0","type":"link"}