{"product_id":"sp-c-antibody-sc-f2479","title":"Prosurfactant Protein C Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eProsurfactant protein C (proSP-C) is a 197-residue integral membrane protein in the endoplasmic reticulum (ER), where its transmembrane (TM) region forms the mature surfactant protein C (SP-C). The C-terminal domain (CTC, residues 59-197), located in the ER lumen, contains a Brichos domain (residues 94-197) that plays a crucial role in preventing amyloid formation of the poly-Val TM region during biosynthesis. Depending on the literature source, SP-C may also be discussed as Prosurfactant Protein C and proSP-C.\u003c\/p\u003e\u003cp\u003eReported cellular context includes secreted and surface film, which can matter when signal is compared across treatments or changing cell states. Following SP-C across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eSP-C is commonly interpreted in the context of metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans secreted and surface film, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between secreted and surface film across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for SP-C. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in SP-C reflect biology rather than handling. When interpreting SP-C, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep SP-C trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577953952089,"sku":"F2479-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577953984857,"sku":"F2479-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577954017625,"sku":"F2479-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/f2479-IHC1.jpg?v=1773600446","url":"https:\/\/absource.de\/products\/sp-c-antibody-sc-f2479","provider":"Absource Diagnostics","version":"1.0","type":"link"}