{"product_id":"srt2104-gsk2245840-s7792","title":"SRT2104 (GSK2245840)","description":"\u003cp\u003e\u003cstrong\u003eSRT2104 (GSK2245840)\u003c\/strong\u003e is an activator of Sirtuins used in studies of DNA Damage Response and Epigenetic Regulation. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation in aging, cancer, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy activating Sirtuins, SRT2104 (GSK2245840) can be used to examine checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In aging, cancer, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Sirtuins\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Epigenetic Regulation\u003c\/li\u003e\n\u003cli\u003eGain-of-function pathway-activation studies\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, SRT2104 (GSK2245840) is appropriate when a defined chemical perturbant is needed to connect Sirtuins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in aging, cancer, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809541857625,"sku":"S7792-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809541890393,"sku":"S7792-25MG","price":468.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809541923161,"sku":"S7792-100MG","price":979.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/srt2104-gsk2245840-chemical-structure-s7792.gif?v=1776201861","url":"https:\/\/absource.de\/products\/srt2104-gsk2245840-s7792","provider":"Absource Diagnostics","version":"1.0","type":"link"}