{"product_id":"stat3alpha-antibody-sc-f0511","title":"Stat3α Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eSTAT3ALPHA is a target of interest in many antibody-based workflows. STAT3α is the full-length, canonical isoform of Signal Transducer and Activator of Transcription 3 (STAT3), a latent cytoplasmic transcription factor that mediates signaling downstream of cytokines, growth factors, and hormones, most notably interleukin-6 (IL-6). Structurally, STAT3α contains six functional domains: an N-terminal domain for cooperative DNA binding, a coiled-coil domain mediating protein-protein interactions, a central DNA-binding domain, a linker domain, an SH2 domain required for receptor docking and dimerization, and a C-terminal transactivation domain (TAD) that harbors critical phosphorylation sites at Tyr705 and Ser727. Depending on the literature source, STAT3ALPHA may also be discussed as Signal transducer and activator of transcription 3 and Acute-phase response factor.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and nucleus, which can matter when signal is compared across treatments or changing cell states. Following STAT3ALPHA across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eSTAT3ALPHA is commonly interpreted in the context of cancer, immunology, and developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for STAT3ALPHA. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in STAT3ALPHA reflect biology rather than handling. When interpreting STAT3ALPHA, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep STAT3ALPHA trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577466233177,"sku":"F0511-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577466265945,"sku":"F0511-100UL","price":359.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577466298713,"sku":"F0511-2X100UL","price":539.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0511-IF.png?v=1773598561","url":"https:\/\/absource.de\/products\/stat3alpha-antibody-sc-f0511","provider":"Absource Diagnostics","version":"1.0","type":"link"}