{"product_id":"stat6-antibody-sc-f0555","title":"Phospho-STAT6 (Tyr641) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePhospho-STAT6 (Tyr 641) refers to the activated form of STAT6, a transcription factor phosphorylated at tyrosine residue 641. This phosphorylation occurs upon stimulation by cytokines IL-4 and IL-13 through JAK1 activation. Phosphorylated STAT6 dimerizes and translocates to the nucleus, where it binds DNA to regulate genes involved in immune responses, particularly promoting T helper 2 (Th2) cell differentiation and IgE production. Depending on the literature source, STAT6 may also be discussed as Phospho-STAT6 (Tyr641) and STAT6 (phospho Y641).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and nucleus, which can matter when signal is compared across treatments or changing cell states. Following STAT6 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eSTAT6 is commonly interpreted in the context of immunology and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for STAT6. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in STAT6 reflect biology rather than handling. When interpreting STAT6, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep STAT6 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577470394713,"sku":"F0555-20UL","price":189.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577470427481,"sku":"F0555-100UL","price":389.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577470460249,"sku":"F0555-2X100UL","price":579.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0555-IF.png?v=1773598617","url":"https:\/\/absource.de\/products\/stat6-antibody-sc-f0555","provider":"Absource Diagnostics","version":"1.0","type":"link"}