{"product_id":"substance-p-tfa-p1129","title":"Substance P TFA","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eSubstance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The mapped target for this entry is Neurokinin 1 receptor (TACR1). This target context is most often investigated as part of ligand-responsive signaling, where receptor occupancy can reshape downstream second-messenger output, trafficking, secretion, excitability, or transcriptional programs. Researchers often use this biology in neurobiology studies, where pathway perturbation can shape neuronal activity, synaptic organization, glial responses, and neurodegenerative phenotypes. In practical terms, this makes the product most relevant to experiments that need a defined and reversible way to perturb biology over short time scales.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eAs an agonist-format peptide, it is typically used to trigger pathway activation on demand and to compare acute signaling events with longer adaptive changes such as receptor desensitization or altered transcriptional output. In practice, dose-response design, timing, and matched control conditions are important for separating direct target engagement from delayed compensatory responses.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003epair peptide treatment with pathway-proximal signaling or trafficking readouts whenever possible\u003c\/li\u003e\n\u003cli\u003ecompare responses across cell states or model systems with different receptor abundance\u003c\/li\u003e\n\u003cli\u003edistinguish primary target engagement from downstream adaptation during longer incubations\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eExperimental interpretation should therefore connect early pathway changes with later phenotypic outputs, rather than relying on a single endpoint in isolation.\u003c\/p\u003e\u003ch2\u003eFormat Considerations\u003c\/h2\u003e\u003cp\u003eThe standard product format is most useful for reproducible baseline experiments, matched comparative studies, and workflows that need a consistent reagent across assay repeats. In comparative workflows, keeping the listed tfa format constant across comparator groups can reduce avoidable formulation-related differences. This is particularly helpful for comparative experiments, benchmark studies, and orthogonal validation in which small differences in formulation or handling can complicate interpretation. For peptide-centered workflows, conclusions are usually strongest when biological readouts are paired with consistent preparation and appropriately matched reference conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57636823236953,"sku":"P1129-5MG","price":146.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57636823269721,"sku":"P1129-25MG","price":439.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/p1129-substance-p-tfa-chemical-structure.png?v=1774212402","url":"https:\/\/absource.de\/products\/substance-p-tfa-p1129","provider":"Absource Diagnostics","version":"1.0","type":"link"}