{"product_id":"tenovin-1-s8000","title":"Tenovin-1","description":"\u003cp\u003e\u003cstrong\u003eTenovin-1\u003c\/strong\u003e is an activator of p53 and MDM2 used in studies of Apoptosis and Protein Degradation \/ Proteasome and related signaling programs. In practice, this places the compound in experiments that measure caspase-associated cell-death signaling and survival decisions and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation in apoptosis, cancer, and cell cycle models.\u003c\/p\u003e\n\n\u003cp\u003eBy activating p53 and MDM2, Tenovin-1 can be used to examine caspase-associated cell-death signaling and survival decisions and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. This context is compatible with apoptosis, viability, and caspase-readout assays and degradation, proteasome, and protein-turnover assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In apoptosis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving p53 and MDM2\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Apoptosis and Protein Degradation \/ Proteasome and related signaling programs\u003c\/li\u003e\n\u003cli\u003eGain-of-function pathway-activation studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in apoptosis, cancer, and cell cycle models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Tenovin-1 is appropriate when a defined chemical perturbant is needed to connect p53 and MDM2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809568006489,"sku":"S8000-10MG","price":68.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809568039257,"sku":"S8000-50MG","price":265.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Tenovin-1-chemical-structure-s8000.gif?v=1776202173","url":"https:\/\/absource.de\/products\/tenovin-1-s8000","provider":"Absource Diagnostics","version":"1.0","type":"link"}