{"product_id":"thioguanine-s1774","title":"Thioguanine","description":"\u003cp\u003e\u003cstrong\u003eThioguanine\u003c\/strong\u003e is an inhibitor of DNA Methyltransferases and Transferases used in studies of Protein Degradation \/ Proteasome and Epigenetic Regulation and related signaling programs. It is especially relevant in cancer, epigenetics, and metabolism models, where defined compound exposure can be linked to ubiquitin-dependent turnover, proteostasis, and targeted protein degradation and chromatin-state control, histone modification, and transcriptional regulation.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting DNA Methyltransferases and Transferases, Thioguanine can be used to examine ubiquitin-dependent turnover, proteostasis, and targeted protein degradation and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In cancer, epigenetics, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving DNA Methyltransferases and Transferases\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Protein Degradation \/ Proteasome and Epigenetic Regulation and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Thioguanine is appropriate when a defined chemical perturbant is needed to connect DNA Methyltransferases and Transferases with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, epigenetics, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"50 mg","offer_id":57805350535513,"sku":"S1774-50MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg","offer_id":57805350568281,"sku":"S1774-500MG","price":291.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Thioguanine-chemical-structure-S1774.gif?v=1776174021","url":"https:\/\/absource.de\/products\/thioguanine-s1774","provider":"Absource Diagnostics","version":"1.0","type":"link"}