{"product_id":"tim-3-antibody-sc-f2147","title":"TIM 3 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTim-3 (T-cell immunoglobulin and mucin-domain containing-3) is a multifaceted immune checkpoint receptor that plays a vital role in regulating T-cell responses and maintaining immune homeostasis. It is expressed in T cells, dendritic cells, and macrophages, promotes immune tolerance, and modulates immune activation. In autoimmune diseases like multiple sclerosis and rheumatoid arthritis, Tim-3 functions predominantly as an inhibitory molecule, curbing excessive Th1-driven inflammation and preserving immune balance. Depending on the literature source, TIM-3 may also be discussed as TIM 3.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell junction, cell membrane, and membrane, which can matter when signal is compared across treatments or changing cell states. Following TIM-3 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTIM-3 is commonly interpreted in the context of immunology and inflammation research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell junction, cell membrane, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell junction, cell membrane, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TIM-3. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TIM-3 reflect biology rather than handling. When interpreting TIM-3, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TIM-3 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577872425305,"sku":"F2147-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577872458073,"sku":"F2147-100UL","price":419.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577872490841,"sku":"F2147-2X100UL","price":629.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2147-IHC1.jpg?v=1773600216","url":"https:\/\/absource.de\/products\/tim-3-antibody-sc-f2147","provider":"Absource Diagnostics","version":"1.0","type":"link"}