{"product_id":"tmem49-vmp1-antibody-sc-f1488","title":"TMEM49\/VMP1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTMEM49\/VMP1 is a target of interest in many antibody-based workflows. Vacuole membrane protein 1 (VMP1), also known as TMEM49, is an integral membrane protein with seven transmembrane domains and 406 amino acids, essential for autophagy and ER-lipid transport. Structurally, it interacts with autophagy factors like Beclin1 and TMEM41B to facilitate autophagosome formation, lipid transport from the ER, and fusion with lysosomes. Depending on the literature source, TMEM49\/VMP1 may also be discussed as TMEM49\/VMP1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, endoplasmic reticulum, membrane, and vacuole, which can matter when signal is compared across treatments or changing cell states. Following TMEM49\/VMP1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTMEM49\/VMP1 is commonly interpreted in the context of metabolism, infectious disease, and autophagy research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, endoplasmic reticulum, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, endoplasmic reticulum, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003ehost-response changes during infection or pathogen-associated stimulation\u003c\/li\u003e\n\u003cli\u003einterpretation alongside flux, cargo handling, or lysosomal context\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TMEM49\/VMP1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TMEM49\/VMP1 reflect biology rather than handling. When interpreting TMEM49\/VMP1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TMEM49\/VMP1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577761898841,"sku":"F1488-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577761931609,"sku":"F1488-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577761964377,"sku":"F1488-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1488-wb.gif?v=1773599810","url":"https:\/\/absource.de\/products\/tmem49-vmp1-antibody-sc-f1488","provider":"Absource Diagnostics","version":"1.0","type":"link"}