{"product_id":"tnfaip3-antibody-sc-f3346","title":"A20\/TNFAIP3 (J7N7) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTNFAIP3 (A20) is a critical ubiquitin-editing enzyme encoded by the TNFAIP3 gene, functioning as a key negative regulator of inflammation and immune responses. It is rapidly induced by pro-inflammatory stimuli such as TNF-α, IL-1β, and LPS, and primarily acts to terminate NF-κB signalling. TNFAIP3 contains an N-terminal ovarian tumor (OTU) domain with deubiquitinating (DUB) activity and multiple zinc finger (ZnF) motifs in the C-terminal region, which confer E3 ubiquitin ligase and ubiquitin-binding capabilities. Depending on the literature source, TNFAIP3 may also be discussed as A20\/TNFAIP3.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, lysosome, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following TNFAIP3 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTNFAIP3 is commonly interpreted in the context of cancer, inflammation, and cardiovascular research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, lysosome, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, lysosome, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TNFAIP3. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TNFAIP3 reflect biology rather than handling. When interpreting TNFAIP3, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TNFAIP3 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578016440665,"sku":"F3346-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578016473433,"sku":"F3346-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578016506201,"sku":"F3346-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3346-wb.gif?v=1773601133","url":"https:\/\/absource.de\/products\/tnfaip3-antibody-sc-f3346","provider":"Absource Diagnostics","version":"1.0","type":"link"}