{"product_id":"tozasertib-vx-680-mk-0457-s1048","title":"Tozasertib (VX-680, MK-0457)","description":"\u003cp\u003e\u003cstrong\u003eTozasertib (VX-680, MK-0457)\u003c\/strong\u003e is an inhibitor of Aurora Kinases and FLT3 and related targets used in studies of MAPK \/ ERK Signaling and JAK-STAT Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in apoptosis, autophagy, and cancer models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Aurora Kinases and FLT3 and related targets, Tozasertib (VX-680, MK-0457) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Aurora Kinases and FLT3 and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and JAK-STAT Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Tozasertib (VX-680, MK-0457) is appropriate when a defined chemical perturbant is needed to connect Aurora Kinases and FLT3 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"25 mg","offer_id":57805188563289,"sku":"S1048-25MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805188596057,"sku":"S1048-100MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":57805188628825,"sku":"S1048-250MG","price":461.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805188661593,"sku":"S1048-1G","price":1837.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805188694361,"sku":"S1048-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/VX-680-MK-0457-chemical-structure-S1048.gif?v=1776172812","url":"https:\/\/absource.de\/products\/tozasertib-vx-680-mk-0457-s1048","provider":"Absource Diagnostics","version":"1.0","type":"link"}