{"product_id":"tp53-antibody-sc-f2366","title":"Phospho-p53 (Ser37) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTP53 is a target of interest in many antibody-based workflows. Phospho-p53 (Ser 37) is a tightly regulated nuclear phosphoprotein and transcription factor composed of 393 amino acids, structurally organized into four key domains: an N-terminal transactivation domain (which includes Ser37), a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain. It is minimally expressed under normal conditions but is rapidly induced in response to cellular stress, such as DNA damage or hypoxia. Depending on the literature source, TP53 may also be discussed as Phospho-p53 (Ser37) and p53 (phospho S37).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytoskeleton, endoplasmic reticulum, and mitochondrion, which can matter when signal is compared across treatments or changing cell states. Following TP53 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTP53 is commonly interpreted in the context of cancer, dna damage \/ repair, and cell cycle research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoskeleton, and endoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytoskeleton, and endoplasmic reticulum across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003ecell-cycle linked differences in abundance, timing, or compartmental enrichment\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TP53. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TP53 reflect biology rather than handling. When interpreting TP53, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TP53 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577921085785,"sku":"F2366-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577921118553,"sku":"F2366-100UL","price":349.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577921151321,"sku":"F2366-2X100UL","price":519.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2366-wb.gif?v=1773600340","url":"https:\/\/absource.de\/products\/tp53-antibody-sc-f2366","provider":"Absource Diagnostics","version":"1.0","type":"link"}