{"product_id":"tp53bp1-antibody-sc-f2158","title":"53BP1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003e53BP1 (p53-binding protein 1), encoded by the TP53BP1 gene on chromosome 15, is a key DNA damage response protein that regulates double-strand break (DSB) repair, particularly through the non-homologous end joining (NHEJ) pathway. Structurally, it is a scaffold protein, featuring N-terminal phosphorylation sites, a Minimal Focus Forming Region (FFR) for chromatin localization, tandem Tudor domains that recognize H4K20me2, and BRCT domains that interact with p53 and γH2AX. Depending on the literature source, TP53BP1 may also be discussed as 53BP1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes centromere, chromosome, kinetochore, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following TP53BP1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTP53BP1 is commonly interpreted in the context of dna damage \/ repair research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans centromere, chromosome, and kinetochore, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between centromere, chromosome, and kinetochore across matched conditions\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TP53BP1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TP53BP1 reflect biology rather than handling. When interpreting TP53BP1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TP53BP1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577876193625,"sku":"F2158-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577876226393,"sku":"F2158-100UL","price":399.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577876259161,"sku":"F2158-2X100UL","price":599.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2158-IF.png?v=1773600230","url":"https:\/\/absource.de\/products\/tp53bp1-antibody-sc-f2158","provider":"Absource Diagnostics","version":"1.0","type":"link"}