{"product_id":"tpca-1-s2824","title":"TPCA-1","description":"\u003cp\u003e\u003cstrong\u003eTPCA-1\u003c\/strong\u003e is an inhibitor of IKK and NF-kB and related targets used in studies of JAK-STAT Signaling and NF-kB Signaling and related signaling programs. It is especially relevant in apoptosis, cancer, and cell signaling models, where defined compound exposure can be linked to cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting IKK and NF-kB and related targets, TPCA-1 can be used to examine cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving IKK and NF-kB and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to JAK-STAT Signaling and NF-kB Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, TPCA-1 is appropriate when a defined chemical perturbant is needed to connect IKK and NF-kB and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57805786218841,"sku":"S2824-10MG","price":167.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805786251609,"sku":"S2824-50MG","price":461.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805786284377,"sku":"S2824-1G","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805786317145,"sku":"S2824-1ML\/DMSO","price":216.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/TPCA-1-chemical-structure-s2824.gif?v=1776175782","url":"https:\/\/absource.de\/products\/tpca-1-s2824","provider":"Absource Diagnostics","version":"1.0","type":"link"}