{"product_id":"tpen-s6962","title":"TPEN","description":"\u003cp\u003e\u003cstrong\u003eTPEN\u003c\/strong\u003e is a modulator of NOS used in studies of DNA Damage Response and Apoptosis and related signaling programs. It is especially relevant in apoptosis, cancer, and cardiovascular models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions.\u003c\/p\u003e\n\n\u003cp\u003eBy modulating NOS, TPEN can be used to examine checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cardiovascular models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving NOS\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Apoptosis and related signaling programs\u003c\/li\u003e\n\u003cli\u003eContext-dependent response profiling and mechanism comparison\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, TPEN is appropriate when a defined chemical perturbant is needed to connect NOS with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cardiovascular models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"25 mg","offer_id":57809442996569,"sku":"S6962-25MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809443029337,"sku":"S6962-1G","price":953.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s6962-tpen-chemical-structure.gif?v=1776200745","url":"https:\/\/absource.de\/products\/tpen-s6962","provider":"Absource Diagnostics","version":"1.0","type":"link"}