{"product_id":"trametinib-dmso-solvate-gsk1120212b-s4484","title":"Trametinib DMSO solvate (GSK1120212B)","description":"\u003cp\u003e\u003cstrong\u003eTrametinib DMSO solvate (GSK1120212B)\u003c\/strong\u003e is an inhibitor of MEK1 and MEK2 used in studies of MAPK \/ ERK Signaling and Apoptosis and related signaling programs. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and caspase-associated cell-death signaling and survival decisions in apoptosis, autophagy, and cancer models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting MEK1 and MEK2, Trametinib DMSO solvate (GSK1120212B) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and caspase-associated cell-death signaling and survival decisions. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving MEK1 and MEK2\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and Apoptosis and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Trametinib DMSO solvate (GSK1120212B) is appropriate when a defined chemical perturbant is needed to connect MEK1 and MEK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 5 mg","offer_id":57809052074329,"sku":"S4484-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 25 mg","offer_id":57809052107097,"sku":"S4484-25MG","price":291.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 mg","offer_id":57809052139865,"sku":"S4484-100MG","price":734.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 g","offer_id":57809052172633,"sku":"S4484-1G","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 5 mg","offer_id":58478672413017,"sku":"C10165-5MG","price":108.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 25 mg","offer_id":58478672445785,"sku":"C10165-25MG","price":217.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 mg","offer_id":58478672478553,"sku":"C10165-100MG","price":548.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 1 g","offer_id":58478672511321,"sku":"C10165-1G","price":2195.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s4484-trametinib-dmso-solvate-chemical-structure.gif?v=1776196489","url":"https:\/\/absource.de\/products\/trametinib-dmso-solvate-gsk1120212b-s4484","provider":"Absource Diagnostics","version":"1.0","type":"link"}