{"product_id":"tropifexor-ljn452-s8733","title":"Tropifexor (LJN452)","description":"\u003cp\u003e\u003cstrong\u003eTropifexor (LJN452)\u003c\/strong\u003e is an agonist of FXR used in studies of GPCR Signaling and Hormone Signaling and related signaling programs. In practice, this places the compound in experiments that measure receptor-driven second-messenger signaling and desensitization dynamics and ligand-dependent transcriptional programs and endocrine regulation in endocrinology and metabolism models.\u003c\/p\u003e\n\n\u003cp\u003eBy activating FXR, Tropifexor (LJN452) can be used to examine receptor-driven second-messenger signaling and desensitization dynamics and ligand-dependent transcriptional programs and endocrine regulation. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In endocrinology and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving FXR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling and Hormone Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eAgonist-response and downstream signaling studies\u003c\/li\u003e\n\u003cli\u003eReporter-gene, receptor-binding, and transcriptional assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Tropifexor (LJN452) is appropriate when a defined chemical perturbant is needed to connect FXR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in endocrinology and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"2 mg","offer_id":57809641603417,"sku":"S8733-2MG","price":242.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57809641636185,"sku":"S8733-10MG","price":776.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/tropifexor-ljn52-chemical-structure-s8733.gif?v=1776204679","url":"https:\/\/absource.de\/products\/tropifexor-ljn452-s8733","provider":"Absource Diagnostics","version":"1.0","type":"link"}