{"product_id":"tsc2-antibody-sc-f0311","title":"Tuberin\/TSC2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTuberous sclerosis complex (TSC) is a syndrome caused by mutations in either the TSC1 or TSC2 tumor suppressor genes. It is characterized by seizures, mental retardation, autism, and the development of tumors in various organs, including the brain, kidney, heart, retina, and skin. TSC2 encodes a protein called tuberin, which plays a critical role in regulating cell proliferation and tumor formation. Depending on the literature source, TSC2 may also be discussed as Tuberin\/TSC2 and Tuberin.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, lysosome, and membrane, which can matter when signal is compared across treatments or changing cell states. Following TSC2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTSC2 is commonly interpreted in the context of cancer, neuroscience, and endocrinology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, lysosome, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, lysosome, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003eresponses to hormone-dependent signaling or endocrine feedback context\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TSC2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TSC2 reflect biology rather than handling. When interpreting TSC2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TSC2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577440674137,"sku":"F0311-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577440706905,"sku":"F0311-100UL","price":359.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577440739673,"sku":"F0311-2X100UL","price":539.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0311-IF.png?v=1773598321","url":"https:\/\/absource.de\/products\/tsc2-antibody-sc-f0311","provider":"Absource Diagnostics","version":"1.0","type":"link"}