{"product_id":"uqcrb-antibody-sc-f3614","title":"UQCRB Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eUQCRB (Ubiquinol-cytochrome c reductase binding protein) is a nuclear-encoded subunit of mitochondrial complex III, located at chromosome 8q22, and plays a vital role in stabilizing the ubisemiquinone radical via hydrophobic interactions with ubiquinone. Structurally, it is homologous to the yeast Qcr7 subunit and is positioned at the matrix-inner mitochondrial membrane interface, where it interacts with cytochrome b during early complex III assembly, essential for hemylated cytochrome b stabilization.\u003c\/p\u003e\u003cp\u003eReported cellular context includes membrane, mitochondrion, and mitochondrion inner membrane, which can matter when signal is compared across treatments or changing cell states. Following UQCRB across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eUQCRB is commonly interpreted in the context of metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans membrane, mitochondrion, and mitochondrion inner membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between membrane, mitochondrion, and mitochondrion inner membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for UQCRB. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in UQCRB reflect biology rather than handling. When interpreting UQCRB, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep UQCRB trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578035642713,"sku":"F3614-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578035675481,"sku":"F3614-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578035708249,"sku":"F3614-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3614-IF.png?v=1773601332","url":"https:\/\/absource.de\/products\/uqcrb-antibody-sc-f3614","provider":"Absource Diagnostics","version":"1.0","type":"link"}