{"product_id":"usp11-antibody-sc-f2498","title":"USP11 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eUSP11 (Ubiquitin-Specific Protease 11) is a nuclear-localized deubiquitinating enzyme encoded on chromosome Xp11. 23, with a molecular weight of ~105-110 kDa. It features an N-terminal DU module, composed of DUSP and UBL domains, followed by a catalytic protease domain with an internal UBL2 insertion, resulting in a monomeric protein with structural properties distinct from those of its homologs USP4 and USP15. Depending on the literature source, USP11 may also be discussed as UHX1 and Ubiquitin carboxyl-terminal hydrolase 11.\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome, cytoplasm, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following USP11 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eUSP11 is commonly interpreted in the context of dna damage \/ repair research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome, cytoplasm, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome, cytoplasm, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for USP11. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in USP11 reflect biology rather than handling. When interpreting USP11, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep USP11 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577955492185,"sku":"F2498-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577955524953,"sku":"F2498-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577955557721,"sku":"F2498-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2498-wb.gif?v=1773600471","url":"https:\/\/absource.de\/products\/usp11-antibody-sc-f2498","provider":"Absource Diagnostics","version":"1.0","type":"link"}