{"product_id":"vadimezan-dmxaa-s1537","title":"Vadimezan (DMXAA)","description":"\u003cp\u003e\u003cstrong\u003eVadimezan (DMXAA)\u003c\/strong\u003e is an agonist of TNF-alpha used in studies of NF-kB Signaling and Immune Signaling. In practice, this places the compound in experiments that measure inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses in angiogenesis, cancer, and immunology models.\u003c\/p\u003e\n\n\u003cp\u003eBy activating TNF-alpha, Vadimezan (DMXAA) can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving TNF-alpha\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to NF-kB Signaling and Immune Signaling\u003c\/li\u003e\n\u003cli\u003eAgonist-response and downstream signaling studies\u003c\/li\u003e\n\u003cli\u003eImmune-cell activation, cytokine, and mediator assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Vadimezan (DMXAA) is appropriate when a defined chemical perturbant is needed to connect TNF-alpha with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805306397017,"sku":"S1537-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57805306429785,"sku":"S1537-10MG","price":242.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805306462553,"sku":"S1537-25MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805306495321,"sku":"S1537-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805306528089,"sku":"S1537-1G","price":1444.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805306560857,"sku":"S1537-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/DMXAA-ASA404-chemical-structure-S1537.gif?v=1776173696","url":"https:\/\/absource.de\/products\/vadimezan-dmxaa-s1537","provider":"Absource Diagnostics","version":"1.0","type":"link"}