{"product_id":"vcp-antibody-sc-f1019","title":"VCP Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eValosin containing protein (VCP) is a chaperone-like protein that plays a crucial role in maintaining cellular proteostasis. Its primary function involves identifying and eliminating ubiquitinated proteins from various cellular locations, such as membranes, protein complexes, aggregates, and chromatin. VCP then regulates their ubiquitination or de-ubiquitination and facilitates their degradation through the ubiquitin-proteasome system (UPS) or the autophagic pathway.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytosol, endoplasmic reticulum, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following VCP across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eVCP is commonly interpreted in the context of inflammation research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytosol, and endoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytosol, and endoplasmic reticulum across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for VCP. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in VCP reflect biology rather than handling. When interpreting VCP, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep VCP trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577591734617,"sku":"F1019-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577591767385,"sku":"F1019-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577591800153,"sku":"F1019-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1019-IHC1.jpg?v=1773599196","url":"https:\/\/absource.de\/products\/vcp-antibody-sc-f1019","provider":"Absource Diagnostics","version":"1.0","type":"link"}