{"product_id":"vdr-antibody-sc-f0766","title":"Vitamin D3 Receptor Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eThe vitamin D3 receptor (VDR\/NR1I1) and its ligand 1-α, 25-dihydroxycholecalciferol [1α, 25(OH)2D3] are now understood to exert biological effects in nearly every tissue of the human body. Vitamin D signaling targets include the central nervous system, skin, immune system, endocrine glands, kidney, and colon. At the cellular level, vitamin D signaling impacts proliferation, differentiation, and apoptosis in both normal and transformed cells. Depending on the literature source, VDR may also be discussed as Vitamin D3 Receptor and Vitamin D Receptor.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and nucleus, which can matter when signal is compared across treatments or changing cell states. Following VDR across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eVDR is commonly interpreted in the context of endocrinology and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses to hormone-dependent signaling or endocrine feedback context\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for VDR. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in VDR reflect biology rather than handling. When interpreting VDR, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep VDR trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577516400985,"sku":"F0766-20UL","price":179.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577516433753,"sku":"F0766-100UL","price":339.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577516466521,"sku":"F0766-2X100UL","price":499.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0766-IHC1.jpg?v=1773598907","url":"https:\/\/absource.de\/products\/vdr-antibody-sc-f0766","provider":"Absource Diagnostics","version":"1.0","type":"link"}