{"product_id":"ve-cadherin-antibody-sc-f1068","title":"VE-cadherin Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eVE-cadherin, also known as vascular endothelial cadherin or CD144, is a critical transmembrane protein predominantly expressed in endothelial cells, where it plays a vital role in maintaining cell-cell junctions that regulate vascular permeability and integrity. As a member of the cadherin superfamily, VE-cadherin features a unique structure composed of an extracellular domain responsible for homophilic binding to adjacent VE-cadherin molecules, a single transmembrane domain and an intracellular domain that interacts with catenins such as β-catenin and p120-catenin.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell junction, cell membrane, cytoplasm, and membrane, which can matter when signal is compared across treatments or changing cell states. Following VE-CADHERIN across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eVE-CADHERIN is commonly interpreted in the context of immunology, cardiovascular, and angiogenesis research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell junction, cell membrane, and cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell junction, cell membrane, and cytoplasm across matched conditions\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003cli\u003edifferences related to endothelial activation, vessel remodeling, or growth-factor exposure\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for VE-CADHERIN. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in VE-CADHERIN reflect biology rather than handling. When interpreting VE-CADHERIN, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep VE-CADHERIN trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577603137881,"sku":"F1068-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577603170649,"sku":"F1068-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577603203417,"sku":"F1068-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1068-wb.gif?v=1773599246","url":"https:\/\/absource.de\/products\/ve-cadherin-antibody-sc-f1068","provider":"Absource Diagnostics","version":"1.0","type":"link"}