{"product_id":"verubecestat-mk-8931-s8564","title":"Verubecestat (MK-8931)","description":"\u003cp\u003e\u003cstrong\u003eVerubecestat (MK-8931)\u003c\/strong\u003e is an inhibitor of BACE used in studies of protease biology. In practice, this places the compound in experiments that measure proteolytic processing and cleavage-dependent signaling in neuroscience models. Dose-response comparison, orthogonal validation, and secondary assay follow-up can further sharpen mechanistic interpretation.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting BACE, Verubecestat (MK-8931) can be used to examine proteolytic processing and cleavage-dependent signaling. This target class is commonly examined through protease-activity, cleavage, and substrate-processing assays, together with downstream-response mapping. In neuroscience models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving BACE\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eProtease-activity, cleavage, and substrate-processing assays\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in neuroscience models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Verubecestat (MK-8931) is appropriate when a defined chemical perturbant is needed to connect BACE with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in neuroscience models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 5 mg","offer_id":57809621352793,"sku":"S8564-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 25 mg","offer_id":57809621385561,"sku":"S8564-25MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 ml (10mM\/DMSO)","offer_id":57809621418329,"sku":"S8564-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 5 mg","offer_id":58479018770777,"sku":"C13500-5MG","price":108.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 25 mg","offer_id":58479018803545,"sku":"C13500-25MG","price":271.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/verubecestat-mk-8931-chemical-structure-S8564.gif?v=1776202969","url":"https:\/\/absource.de\/products\/verubecestat-mk-8931-s8564","provider":"Absource Diagnostics","version":"1.0","type":"link"}