{"product_id":"vx-445-elexacaftor-s8851","title":"VX-445 (Elexacaftor)","description":"\u003cp\u003e\u003cstrong\u003eVX-445 (Elexacaftor)\u003c\/strong\u003e is a modulator of CFTR used in studies of ion-channel pharmacology. It is especially relevant in cell signaling models, where defined compound exposure can be linked to ion conductance, membrane potential, and electrophysiological responses. Dose-response comparison, orthogonal validation, and secondary assay follow-up can further sharpen mechanistic interpretation.\u003c\/p\u003e\n\n\u003cp\u003eBy modulating CFTR, VX-445 (Elexacaftor) can be used to examine ion conductance, membrane potential, and electrophysiological responses. This target class is commonly examined through electrophysiology, ion-flux, and membrane-potential studies, together with downstream-response mapping. In cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CFTR\u003c\/li\u003e\n\u003cli\u003eContext-dependent response profiling and mechanism comparison\u003c\/li\u003e\n\u003cli\u003eElectrophysiology, ion-flux, and membrane-potential studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cell signaling models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, VX-445 (Elexacaftor) is appropriate when a defined chemical perturbant is needed to connect CFTR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 2 mg","offer_id":57809658184025,"sku":"S8851-2MG","price":186.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 5 mg","offer_id":57809658216793,"sku":"S8851-5MG","price":350.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 25 mg","offer_id":57809658249561,"sku":"S8851-25MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 mg","offer_id":57809658282329,"sku":"S8851-100MG","price":2918.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 g","offer_id":57809658315097,"sku":"S8851-1G","price":9533.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 ml (10mM\/DMSO)","offer_id":57809658347865,"sku":"S8851-1ML\/DMSO","price":390.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 2 mg","offer_id":58479075656025,"sku":"C13720-2MG","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 5 mg","offer_id":58479075688793,"sku":"C13720-5MG","price":261.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 25 mg","offer_id":58479075721561,"sku":"C13720-25MG","price":712.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 mg","offer_id":58479075754329,"sku":"C13720-100MG","price":2179.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 1 g","offer_id":58479075787097,"sku":"C13720-1G","price":7117.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/elexacaftor-chemical-structure-s8851.gif?v=1776204794","url":"https:\/\/absource.de\/products\/vx-445-elexacaftor-s8851","provider":"Absource Diagnostics","version":"1.0","type":"link"}