{"product_id":"vx-984-s8593","title":"VX-984","description":"\u003cp\u003e\u003cstrong\u003eVX-984\u003c\/strong\u003e is an inhibitor of DNA-PK used in studies of DNA Damage Response. It is especially relevant in cancer, cell signaling, and dna damage \/ repair models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting DNA-PK, VX-984 can be used to examine checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving DNA-PK\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, VX-984 is appropriate when a defined chemical perturbant is needed to connect DNA-PK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"1 mg","offer_id":57809626071385,"sku":"S8593-1MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57809626104153,"sku":"S8593-5MG","price":341.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809626136921,"sku":"S8593-25MG","price":763.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809626169689,"sku":"S8593-100MG","price":1739.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/S8593-VX-984-chemical-structure.png?v=1776203016","url":"https:\/\/absource.de\/products\/vx-984-s8593","provider":"Absource Diagnostics","version":"1.0","type":"link"}