{"product_id":"whsc1-nsd2-antibody-sc-f2195","title":"WHSC1\/NSD2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eWHSC1\/NSD2 is a target of interest in many antibody-based workflows. The Nuclear Receptor Binding SET Domain Protein 2 (NSD2, also known as MMSET or WHSC1) is a histone methyltransferase and a member of the NSD family, responsible for catalyzing mono-, di-, and trimethylation of lysines on histones, particularly H3K36, H3K4, H3K9, H3K27, and H4K20. Structurally, NSD2 consists of 1365 amino acids and includes a SET domain for methyltransferase activity and an HMG domain that interacts with androgen receptors to facilitate nuclear translocation. Depending on the literature source, WHSC1\/NSD2 may also be discussed as WHSC1\/NSD2 and WHSC1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome, cytoplasm, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following WHSC1\/NSD2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eWHSC1\/NSD2 is commonly interpreted in the context of cancer, dna damage \/ repair, and epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome, cytoplasm, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome, cytoplasm, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for WHSC1\/NSD2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in WHSC1\/NSD2 reflect biology rather than handling. When interpreting WHSC1\/NSD2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep WHSC1\/NSD2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577890775385,"sku":"F2195-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577890808153,"sku":"F2195-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577890840921,"sku":"F2195-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2195-wb.gif?v=1773600270","url":"https:\/\/absource.de\/products\/whsc1-nsd2-antibody-sc-f2195","provider":"Absource Diagnostics","version":"1.0","type":"link"}