{"product_id":"withaferin-a-wfa-s8587","title":"Withaferin A (WFA)","description":"\u003cp\u003e\u003cstrong\u003eWithaferin A (WFA)\u003c\/strong\u003e is an inhibitor of NF-kB used in studies of NF-kB Signaling and Immune Signaling. It is especially relevant in immunology and inflammation models, where defined compound exposure can be linked to inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting NF-kB, Withaferin A (WFA) can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving NF-kB\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to NF-kB Signaling and Immune Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Withaferin A (WFA) is appropriate when a defined chemical perturbant is needed to connect NF-kB with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"1 mg","offer_id":57809623875929,"sku":"S8587-1MG","price":124.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57809623908697,"sku":"S8587-5MG","price":383.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809623941465,"sku":"S8587-25MG","price":1149.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809623974233,"sku":"S8587-100MG","price":2918.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809624007001,"sku":"S8587-1ML\/DMSO","price":451.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s8587-withaferin-a-chemical-structure.gif?v=1776203009","url":"https:\/\/absource.de\/products\/withaferin-a-wfa-s8587","provider":"Absource Diagnostics","version":"1.0","type":"link"}