{"product_id":"ywhah-antibody-sc-f1222","title":"14-3-3 η Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eYWHAH is a target of interest in many antibody-based workflows. 14-3-3 η is an intracellular protein isoform of the 14-3-3 family that functions primarily as a homo- or heterodimer, playing critical roles in cell proliferation, differentiation, and apoptosis by binding phosphorylated serine\/threonine residues on target proteins. Each monomer is composed of nine α-helices arranged in an antiparallel “flattened horseshoe” shape, forming a central amphipathic groove for ligand binding. Depending on the literature source, YWHAH may also be discussed as 14-3-3 eta.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, synapse, and mitochondrion, which can matter when signal is compared across treatments or changing cell states. Following YWHAH across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eYWHAH is commonly interpreted in the context of neuroscience, inflammation, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, synapse, and mitochondrion, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, synapse, and mitochondrion across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for YWHAH. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in YWHAH reflect biology rather than handling. When interpreting YWHAH, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep YWHAH trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577663922521,"sku":"F1222-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577663955289,"sku":"F1222-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577663988057,"sku":"F1222-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1222-wb.gif?v=1773599463","url":"https:\/\/absource.de\/products\/ywhah-antibody-sc-f1222","provider":"Absource Diagnostics","version":"1.0","type":"link"}