Desmoglein-2 (DSG2) Antibody
Description
Anti-Desmoglein-2 (DSG2) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Desmoglein-2, also known as Cadherin family member 5 (CDHF5), is encoded by the DSG2 gene in human. Desmoglein-2 is a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmoglein-2 contains an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The extracellular domain mediates intercellular interactions in the desmosome whereas the intracellular domain mediates Desmoglein-2 interaction with Plakophilins. Desmoglein-2 is highly expressed in the epithelium as well as in the cardiac muscle. In the cardiac muscle, Desmoglein-2 is localized to the intercalated discs which mechanically couple cardiac cells to function in a coordinated syncytial structure.
| Application: | Immunofluorescence, Immunohistochemistry, Western Blot |
|---|---|
| Clonality: | Polyclonal |
| Concentration: | 0.25 mg/ml |
| Conjugation: | Unconjugated |
| Host: | Rat |
| Immunogen: | Synthetic peptide (14-aa) derived from the C-terminal region of human Desmoglein-2 protein |
| Isotype: | IgG |
| Purification: | Affinity Chromatography |
| Reactivity: | Human, Mouse, Rat |
| Species Homology: | Synthetic peptide sequence shows 92.9% homology to mouse or rat sequence |
| Storage: | -20°C |
| Storage Buffer: | PBS, pH 7.2, 0.1% Sodium Azide |