E-Cadherin (Cdh1 or CD324) Antibody



Catalog-Number: 00101


Anti-E-cadherin (Cdh1 or CD324) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. E-cadherin is a protein that is encoded by the Cdh1 gene in human. E-cadherin is also known as Cadherin-1 or CAM 120/80 or uvomorulin or CD324. E-cadherin belongs to the classic cadherin protein superfamily and may act as a tumor suppressor. The cadherin protein features an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The cadherin ectodomain plays an adhesive role whereas the intracellular domain mediates cadherin-catenin interactions. E-cadherin is widely expressed in tissues of epithelial origin. Note that E-cadherin has high sequence similarity to N-cadherin (Cadherin-2). This antibody is developed using an E-cadherin specific sequence.

Application: Immunofluorescence, Immunohistochemistry, Western Blot
Clonality: Polyclonal
Concentration: 0.25 mg/ml
Conjugation: Unconjugated
Host: Rabbit
Immunogen: Synthetic peptide (13-aa) derived from the C-terminal region of human E-cadherin protein
Isotype: IgG
Purification: Affinity Chromatography
Reactivity: Human, Mouse, Rat
Species Homology: Synthetic peptide sequence is identical to mouse or rat sequence (this sequence has no homology to other cadherin isoforms)
Storage: -20°C
Storage Buffer: PBS, pH 7.2, 0.1% Sodium Azide