Integrin alpha-7 (ITGA7) Antibody
Description
Anti-Integrin alpha-7 (ITGA7) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Integrins are transmembrane proteins that facilitate cell-extracellular matrix interactions or focal adhesions. Ligands for Integrins include fibronectin, vitronectin, collagen and laminin. An integrin molecule is composed of two protein subunits, alpha and beta. Each subunit consists in an extracellular domain, a single transmembrane domain and a cytoplasmic domain. Integrin alpha-7 protein is encoded by the ITGA7 gene in human. Integrin alpha-7 protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed by the muscle cells and may be involved in differentiation and migration processes during myogenesis. Mutations in ITGA7 cause a recessive form of congenital muscular dystrophy (OMIM 613204). Integrin alpha-7 has many splicing forms. This antibody is raised against the canonical sequence of Integrin alpha-7 (Uniprot #Q61738). It does not bind to the alternatively spliced isoform that has a different C-terminus sequence.
| Application: | Immunofluorescence, Immunohistochemistry, Western Blot |
|---|---|
| Clonality: | Polyclonal |
| Concentration: | 0.25 mg/ml |
| Conjugation: | Unconjugated |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide (19-aa) derived from the C-terminal region of mouse integrin alpha-7 protein (Uniprot #Q61738) |
| Isotype: | IgG |
| Purification: | Affinity Chromatography |
| Reactivity: | Human, Mouse, Rat |
| Species Homology: | Synthetic peptide sequence is identical to rat sequence (showing 84.2% homology to human sequence) |
| Storage: | -20°C |
| Storage Buffer: | PBS, pH 7.2, 0.1% Sodium Azide |