Mucin-1 (MUC1 or CD227) Antibody
Description
Anti-Mucin-1 (MUC1 or CD227) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. Mucin short variant S1, or Mucin-1, also known as epithelial membrane antigen (EMA) or CD227, is a mucin protein encoded by the MUC1 gene in human. Mucin-1 is a membrane-bound protein of the mucin family. Mucin-1 is expressed on the apical surface of epithelial cells that line the mucosal layer of many epithelial tissues such as the lungs, the stomach and the pancreas. Mucin-1 is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling.
| Application: | Immunofluorescence, Immunohistochemistry, Western Blot |
|---|---|
| Clonality: | Polyclonal |
| Concentration: | 0.25 mg/ml |
| Conjugation: | Unconjugated |
| Host: | Rat |
| Immunogen: | Synthetic peptide (13-aa) derived from the C-terminal region of mouse Mucin-1 protein |
| Isotype: | IgG |
| Purification: | Affinity Chromatography |
| Reactivity: | Human, Mouse, Rat |
| Species Homology: | Synthetic peptide sequence is identical to rat sequence (showing 84.6% homology to human sequence) |
| Storage: | -20°C |
| Storage Buffer: | PBS, pH 7.2, 0.1% Sodium Azide |