Nectin-2 (HVEB or CD112) Antibody
Description
Anti-Nectin-2 (HVEB or CD112) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 or CD112 (formerly herpesvirus entry mediator B, HVEB), is a member of the Nectin protein family and also a member of the immunoglobulin superfamily (IgSF), which is encoded by the NECTIN2 gene in human. Nectin-2 is a Ca++-independent cell-cell adhesion molecule that has three extracellular immunoglobulin-like loops, a single transmembrane domain, and a cytoplasmic tail. Nectin-2 serves as an entry point for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses.
| Application: | Immunofluorescence, Immunohistochemistry, Western Blot |
|---|---|
| Clonality: | Polyclonal |
| Concentration: | 0.25 mg/ml |
| Conjugation: | Unconjugated |
| Host: | Rat |
| Immunogen: | Synthetic peptide (14-aa) derived from the C-terminal cytoplasmic region of mouse Nectin-2 protein |
| Isotype: | IgG |
| Purification: | Affinity Chromatography |
| Reactivity: | Human, Mouse, Rat |
| Species Homology: | Synthetic peptide sequence is identical to rat sequence (showing 71.4% homology to human sequence) |
| Storage: | -20°C |
| Storage Buffer: | PBS, pH 7.2, 0.1% Sodium Azide |