Patched-1 (PTCH1 or PTCH) Antibody
Description
Anti-Patched-1 (PTCH1 or PTCH) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Protein patched homolog 1 (patched-1 or PTCH1 or PTCH) is encoded by the PTCH1 gene in human. Patched-1 is a member of the patched protein family and is the receptor for sonic hedgehog , a secreted molecule implicated in embryonic development and in tumorigenesis. Patched-1 is a transmembrane protein that suppresses the activity of smoothened in the absence of sonic hedgehog ligand. When sonic hedgehog binds to patched-1, suppression of smoothened is relieved, which turns on the cell proliferation program.
| Application: | Immunofluorescence, Immunohistochemistry, Western Blot |
|---|---|
| Clonality: | Polyclonal |
| Concentration: | 0.25 mg/ml |
| Conjugation: | Unconjugated |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide (19-aa) derived from the C-terminal intracellular region of mouse patched-1 protein |
| Isotype: | IgG |
| Purification: | Affinity Chromatography |
| Reactivity: | Human, Mouse, Rat |
| Species Homology: | Synthetic peptide sequence is identical to rat sequence (showing 94.7% homology to human sequence) |
| Storage: | -20°C |
| Storage Buffer: | PBS, pH 7.2, 0.1% Sodium Azide |