Patched-1 (PTCH1 or PTCH) Antibody

50701
-20°C

€285.00*

Catalog-Number: 50701

Description

Anti-Patched-1 (PTCH1 or PTCH) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Protein patched homolog 1 (patched-1 or PTCH1 or PTCH) is encoded by the PTCH1 gene in human. Patched-1 is a member of the patched protein family and is the receptor for sonic hedgehog , a secreted molecule implicated in embryonic development and in tumorigenesis. Patched-1 is a transmembrane protein that suppresses the activity of smoothened in the absence of sonic hedgehog ligand. When sonic hedgehog binds to patched-1, suppression of smoothened is relieved, which turns on the cell proliferation program.

Application: Immunofluorescence, Immunohistochemistry, Western Blot
Clonality: Polyclonal
Concentration: 0.25 mg/ml
Conjugation: Unconjugated
Host: Rabbit
Immunogen: Synthetic peptide (19-aa) derived from the C-terminal intracellular region of mouse patched-1 protein
Isotype: IgG
Purification: Affinity Chromatography
Reactivity: Human, Mouse, Rat
Species Homology: Synthetic peptide sequence is identical to rat sequence (showing 94.7% homology to human sequence)
Storage: -20°C
Storage Buffer: PBS, pH 7.2, 0.1% Sodium Azide