Pendrin (Slc26a4) Antibody
Description
Anti-Pendrin (Slc26a4) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Pendrin is an anion exchanger that is encoded by the Slc26a4 gene in human. Pendrin mediates electroneutral exchange of chloride for bicarbonate across the plasma membrane of epithelial cells. Pendrin is a membrane protein with 12 transmembrane domains and molecular weight of 86 kDa. Mutations in Pendrin cause Pendred syndrome or DFNB4 (OMIM 274600), an autosomal recessive disorder characterized by sensorineural deafness and thyroid goiter. Pendrin is highly expressed by the kidney and the inner ear. This antibody can be used with anti-Aqp2 or anti-Atp6v1b1 to differentiate the cell types in kidney collecting ducts.
| Application: | Immunofluorescence, Immunohistochemistry, Western Blot |
|---|---|
| Clonality: | Polyclonal |
| Concentration: | 0.25 mg/ml |
| Conjugation: | Unconjugated |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide (15-aa) derived from the C-terminal region of mouse pendrin protein |
| Isotype: | IgG |
| Purification: | Affinity Chromatography |
| Reactivity: | Human, Mouse, Rat |
| Species Homology: | Synthetic peptide sequence is identical to rat sequence (showing 93.3% homology to human sequence) |
| Storage: | -20°C |
| Storage Buffer: | PBS, pH 7.2, 0.1% Sodium Azide |