Piezo1 (Internal) Antibody
Description
Anti-Piezo1 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent tissues. Piezo-type mechanosensitive ion channel component 1, abbreviated for Piezo1, is encoded by the PIEZO1 gene in human. Piezo1 is the pore-forming subunit of a mechanosensitive nonspecific cation channel, which generates electric currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Piezo1 is a large membrane protein containing 36 transmembrane domains. Piezo1 plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Piezo1 also plays a key role in epithelial cell adhesion by maintaining integrin activation through the R-Ras signaling pathway. Mutations in PIEZO1 have been associated with dehydrated hereditary stomatocytosis in man.
| Application: | Immunofluorescence, Immunohistochemistry, Western Blot |
|---|---|
| Clonality: | Polyclonal |
| Concentration: | 0.25 mg/ml |
| Conjugation: | Unconjugated |
| Host: | Rat |
| Immunogen: | Synthetic peptide (14-aa) derived from the internal region of rat Piezo1 protein |
| Isotype: | IgG |
| Purification: | Affinity Chromatography |
| Reactivity: | Mouse, Rat |
| Species Homology: | Synthetic peptide sequence showing 85.7% homology to mouse sequence and 57.1% homology to human sequence |
| Storage: | -20°C |
| Storage Buffer: | PBS, pH 7.2, 0.1% Sodium Azide |