STK4 (MST1) Antibody
Description
Anti-STK4 (MST1) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Serine/threonine kinase 4 (STK4), also known as MST1, is encoded by the STK4 gene in human. STK4/MST1 is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. STK4/MST1 is part of the Hippo signaling pathway. The Hippo signaling pathway comprises of a kinase cascade wherein MST1/2 phosphorylates and activates LATS1/2, which in turn phosphorylates but inactivates YAP and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
| Application: | Immunofluorescence, Immunohistochemistry, Western Blot |
|---|---|
| Clonality: | Polyclonal |
| Concentration: | 0.25 mg/ml |
| Conjugation: | Unconjugated |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide (18-aa) derived from the C-terminal region of human STK4 protein |
| Isotype: | IgG |
| Purification: | Affinity Chromatography |
| Reactivity: | Human, Mouse, Rat |
| Species Homology: | Synthetic peptide sequence is identical to mouse or rat sequence |
| Storage: | -20°C |
| Storage Buffer: | PBS, pH 7.2, 0.1% Sodium Azide |