VE-Cadherin (Cdh5 or Cadherin-5 or CD144) Antibody
Description
Anti-VE-cadherin (Cdh5 or Cadherin-5 or CD144) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. VE-cadherin is a protein that is encoded by the Cdh5 gene in human. VE-cadherin is also known as Cadherin-5 or CD144. VE-cadherin belongs to the classic cadherin protein superfamily. The cadherin protein features an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The cadherin ectodomain plays an adhesive role whereas the intracellular domain mediates cadherin-catenin interactions. VE-cadherin is exclusively expressed in the endothelium. VE-cadherin is important for the integrity of adherens junction in the endothelium and the permeability across the endothelium.
| Application: | Immunofluorescence, Immunohistochemistry, Western Blot |
|---|---|
| Clonality: | Polyclonal |
| Concentration: | 0.25 mg/ml |
| Conjugation: | Unconjugated |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide (13-aa) derived from the C-terminal region of human VE-cadherin protein |
| Isotype: | IgG |
| Purification: | Affinity Chromatography |
| Reactivity: | Human, Mouse, Rat |
| Species Homology: | Synthetic peptide sequence is identical to mouse or rat sequence |
| Storage: | -20°C |
| Storage Buffer: | PBS, pH 7.2, 0.1% Sodium Azide |