20 (S)-Hydroxycholesterol

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Selleck Chemicals

E7817

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20 (S)-Hydroxycholesterol is an activator of Hedgehog used in studies of Hedgehog Signaling. It is especially relevant in cancer, developmental biology, and immunology models, where defined compound exposure can be linked to morphogen-dependent developmental signaling and transcriptional patterning.

By activating Hedgehog, 20 (S)-Hydroxycholesterol can be used to examine morphogen-dependent developmental signaling and transcriptional patterning. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer, developmental biology, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Hedgehog
  • Pathway perturbation studies connected to Hedgehog Signaling
  • Gain-of-function pathway-activation studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, 20 (S)-Hydroxycholesterol is appropriate when a defined chemical perturbant is needed to connect Hedgehog with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, developmental biology, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Hedgehog
Target Class:
Signaling Pathway Modulator
Pathways:
Hedgehog Signaling
Research Area:
Cancer • Developmental Biology • Immunology • Inflammation
CAS No.:
516-72-3
Molecular Weight:
402.65
SMILES:
CC(C)CCC[C@@](C)(O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C
InChIKey:
MCKLJFJEQRYRQT-MGNSQDQZSA-N
PubChem:
440711
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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