4-Octyl Itaconate (4-OI)
Selleck Chemicals
SKU:S5929-5MG
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4-Octyl Itaconate (4-OI) is an activator of NRF2 used in studies of Oxidative Stress Response. It is especially relevant in immunology, inflammation, and oxidative stress models, where defined compound exposure can be linked to redox signaling, ROS handling, and antioxidant defenses.
By activating NRF2, 4-Octyl Itaconate (4-OI) can be used to examine redox signaling, ROS handling, and antioxidant defenses. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In immunology, inflammation, and oxidative stress models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving NRF2
- Pathway perturbation studies connected to Oxidative Stress Response
- Gain-of-function pathway-activation studies
- Pathway-reporter and mechanistic-phenotyping studies
Overall, 4-Octyl Itaconate (4-OI) is appropriate when a defined chemical perturbant is needed to connect NRF2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology, inflammation, and oxidative stress models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- NRF2
- Target Class:
- Signaling Pathway Modulator
- Pathways:
- Oxidative Stress Response
- Research Area:
- Immunology • Inflammation • Oxidative Stress
- CAS No.:
- 3133-16-2
- Molecular Weight:
- 242.31
- Formula:
- C₁₃H₂₂O₄
- SMILES:
- CCCCCCCCOC(=O)CC(=C)C(=O)O
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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