4-PBA (Sodium Phenylbutyrate)

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Selleck Chemicals

S4125-50MG

€144,00 EUR
€144,00 EUR
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4-PBA (Sodium Phenylbutyrate) is an inhibitor of HDAC used in studies of DNA Damage Response and Epigenetic Regulation. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation in cancer, dna damage / repair, and epigenetics models.

By inhibiting HDAC, 4-PBA (Sodium Phenylbutyrate) can be used to examine checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In cancer, dna damage / repair, and epigenetics models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving HDAC
  • Pathway perturbation studies connected to DNA Damage Response and Epigenetic Regulation
  • Concentration-response inhibition and target-dependence studies
  • Chromatin, epigenetic, and gene-expression profiling

Overall, 4-PBA (Sodium Phenylbutyrate) is appropriate when a defined chemical perturbant is needed to connect HDAC with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, dna damage / repair, and epigenetics models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
HDAC
Target Class:
Epigenetic Regulator
Pathways:
DNA Damage Response • Epigenetic Regulation
Research Area:
Cancer • DNA Damage / Repair • Epigenetics
CAS No.:
1716-12-7
Molecular Weight:
187.19
Formula:
C₁₀H₁₁O₂·Na
SMILES:
C1=CC=C(C=C1)CCCC(=O)[O-].[Na+]
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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