5'-N-Ethylcarboxamidoadenosine (NECA)

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Selleck Chemicals

S6347-5MG

€144,00 EUR
€144,00 EUR
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5'-N-Ethylcarboxamidoadenosine (NECA) is an agonist of Adenosine Receptors and TNF-alpha and related targets used in studies of MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in cardiovascular, cell signaling, and immunology models.

By activating Adenosine Receptors and TNF-alpha and related targets, 5'-N-Ethylcarboxamidoadenosine (NECA) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In cardiovascular, cell signaling, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Adenosine Receptors and TNF-alpha and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs
  • Agonist-response and downstream signaling studies
  • Immune-cell activation, cytokine, and mediator assays

Overall, 5'-N-Ethylcarboxamidoadenosine (NECA) is appropriate when a defined chemical perturbant is needed to connect Adenosine Receptors and TNF-alpha and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cardiovascular, cell signaling, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Adenosine Receptors • TNF-alpha • Interleukins • JNK
Target Class:
Immunomodulator
Pathways:
MAPK / ERK Signaling • JAK-STAT Signaling • NF-kB Signaling
Research Area:
Cardiovascular • Cell Signaling • Immunology • Inflammation
CAS No.:
35920-39-9
Molecular Weight:
308.29
Formula:
C₁₂H₁₆N₆O₄
SMILES:
CCNC(=O)C1OC(C(O)C1O)[N]2C=NC3=C(N)N=CN=C23
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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