A-3 hydrochloride

1 1

Selleck Chemicals

E2506-5MG

€107,00 EUR
€107,00 EUR
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A-3 hydrochloride is an antagonist of PKA and CK2 and related targets used in studies of MAPK / ERK Signaling and GPCR Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and receptor-driven second-messenger signaling and desensitization dynamics in cancer and cell signaling models.

By blocking PKA and CK2 and related targets, A-3 hydrochloride can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and receptor-driven second-messenger signaling and desensitization dynamics. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PKA and CK2 and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and GPCR Signaling
  • Receptor-blockade and ligand-competition studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, A-3 hydrochloride is appropriate when a defined chemical perturbant is needed to connect PKA and CK2 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PKA • CK2 • PKC
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • GPCR Signaling
Research Area:
Cancer • Cell Signaling
CAS No.:
78957-85-4
Molecular Weight:
321.22
Formula:
C₁₂H₁₃ClN₂O₂S·ClH
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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