A-83-01

1 1

Selleck Chemicals

S7692-5X1MG

€144,00 EUR
€144,00 EUR
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A-83-01 is an inhibitor of TGF-beta / Smad used in studies of TGF-beta / Smad Signaling. In practice, this places the compound in experiments that measure Smad-mediated transcription, differentiation, and fibrotic signaling in cancer, cell signaling, and developmental biology models.

By inhibiting TGF-beta / Smad, A-83-01 can be used to examine Smad-mediated transcription, differentiation, and fibrotic signaling. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving TGF-beta / Smad
  • Pathway perturbation studies connected to TGF-beta / Smad Signaling
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, A-83-01 is appropriate when a defined chemical perturbant is needed to connect TGF-beta / Smad with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
TGF-beta / Smad
Target Class:
Signaling Pathway Modulator
Pathways:
TGF-beta / Smad Signaling
Research Area:
Cancer • Cell Signaling • Developmental Biology
CAS No.:
909910-43-6
Molecular Weight:
421.52
Formula:
C₂₅H₁₉N₅S
SMILES:
CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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