A-966492

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Selleck Chemicals

S2197-5MG

€167,00 EUR
€167,00 EUR
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A-966492 is an inhibitor of PARP and PARP1 and related targets used in studies of DNA Damage Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control in cancer and dna damage / repair models.

By inhibiting PARP and PARP1 and related targets, A-966492 can be used to examine checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer and dna damage / repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PARP and PARP1 and related targets
  • Pathway perturbation studies connected to DNA Damage Response
  • Concentration-response inhibition and target-dependence studies
  • Enzyme-activity assays, substrate-conversion studies, and mechanism profiling

Overall, A-966492 is appropriate when a defined chemical perturbant is needed to connect PARP and PARP1 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and dna damage / repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PARP • PARP1 • PARP2
Target Class:
Enzyme
Pathways:
DNA Damage Response
Research Area:
Cancer • DNA Damage / Repair
CAS No.:
934162-61-5
Molecular Weight:
324.35
Formula:
C₁₈H₁₇FN₄O
SMILES:
C1CC(NC1)C2=CC(=C(C=C2)C3=NC4=C(C=CC=C4N3)C(=O)N)F
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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