ABT-737

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Selleck Chemicals

S1002-5MG

€164,00 EUR
€164,00 EUR
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ABT-737 is an inhibitor of BCL-2 used in studies of Apoptosis. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to caspase-associated cell-death signaling and survival decisions in apoptosis and cancer models.

By inhibiting BCL-2, ABT-737 can be used to examine caspase-associated cell-death signaling and survival decisions. This context is compatible with apoptosis, viability, and caspase-readout assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In apoptosis and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving BCL-2
  • Pathway perturbation studies connected to Apoptosis
  • Concentration-response inhibition and target-dependence studies
  • Phenotypic profiling in apoptosis and cancer models

Overall, ABT-737 is appropriate when a defined chemical perturbant is needed to connect BCL-2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
BCL-2
Target Class:
Other
Pathways:
Apoptosis
Research Area:
Apoptosis • Cancer
CAS No.:
852808-04-9
Molecular Weight:
813.43
Formula:
C₄₂H₄₅ClN₆O₅S₂
SMILES:
CN(C)CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]
InChIKey:
HPLNQCPCUACXLM-UHFFFAOYSA-N
PubChem:
11228183
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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