Alobresib (GS-5829)

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Selleck Chemicals

S8961-2MG

€144,00 EUR
€144,00 EUR
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Alobresib (GS-5829) is an inhibitor of BET and NF-kB and related targets used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in apoptosis, cancer, and cell signaling models.

By inhibiting BET and NF-kB and related targets, Alobresib (GS-5829) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving BET and NF-kB and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Chromatin, epigenetic, and gene-expression profiling

Overall, Alobresib (GS-5829) is appropriate when a defined chemical perturbant is needed to connect BET and NF-kB and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
BET • NF-kB • MYC • ERK1
Target Class:
Epigenetic Regulator
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling • NF-kB Signaling
Research Area:
Apoptosis • Cancer • Cell Signaling • Epigenetics
CAS No.:
1637771-14-2
Molecular Weight:
437.49
Formula:
C₂₆H₂₃N₅O₂
SMILES:
CC1=C(C(=NO1)C)C2=CC(=C3C(=C2)NC(=N3)C4CC4)C(C5=CC=CC=N5)(C6=CC=CC=N6)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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